Terapia génica: esperanza para pacientes con isquemia en extremidades

Author: Zhang Jun, Chief Physician of the Vascular Surgery Department at the National Emergency Medical Research Center and the General Emergency Hospital.

Reviewer: Gu Yongquan, Chief Physician of the Vascular Surgery Department at Xuanwu Hospital of Capital Medical University, and Chief Expert in Vascular Surgery at the National Emergency Medical Research Center.

Title: Gene Therapy: Hope for Patients with Limb Ischemia

Profile: Gene therapy provides new options for patients with limb ischemia, improving their quality of life.

Keywords: ['treatment', 'medical innovation']

"Doctor, can my leg be saved?" This is the question most concerning for patients with severe lower limb ischemia. When the vascular condition is too poor to undergo conventional bypass or interventional surgery, patients may feel that treatment is hopeless. However, now, gene therapy, this new technology, offers a new avenue for leg preservation for those considered "inoperable."

"Inoperable" is not the end of the road.

"Inoperable" does not mean there is no hope; it just means that conventional surgical methods are not viable, and we need to explore other treatment options. This often occurs in the following situations:

One of the new therapeutic approaches can be understood as a shift from "external repair" to "self-repair."

Three key weapons: the "life code" of the gene therapy HGF. Among many substances that can promote vascular growth, the "hepatocyte growth factor" (HGF) shows significant results. Not only does it promote the growth of blood vessels, but it also alleviates inflammation and tissue edema, providing a better growth environment for new blood vessels.

Our independently developed Cedomin injectable is based on this principle.

Fourth, real case: good news from clinical trials. A major clinical study (HOPE-CLTI-2) has yielded encouraging results.

Does this concern me? Am I (or is my family) suitable for this?

Possible groups of people who may be suitable:

⚠ Important reminder: Gene therapy is a powerful new method in the "comprehensive treatment plan" for saving limbs, but it is not a "panacea."

Success in limb preservation also requires cooperation with the following basic treatments.

Dear friend:

If you or your family find yourselves in a dead-end situation, feeling helpless and lost, do not lose hope. Every medical advance transforms the "impossible" into the "possible." Gene therapy represents a new stage in the treatment of lower limb ischemia, entering the phase of "neovascularization." It is no longer solely reliant on devices to unblock, but seeks to awaken your body's innate repair capability, allowing your tissues to generate new lifelines on their own. This is a medical idea full of hope: to trust and activate the intrinsic power of life.

We have good news: the Sedomin injection is a medication that has been officially submitted for approval. This innovative therapy promises to help many patients in the near future. It is crucial that you communicate thoroughly with your vascular doctor about your specific situation to jointly assess whether this new option is suitable for you. The best solution for you will always be the personalized plan that your doctor prepares for your case. Maintaining your limbs and walking again, that old dream, is taking steps toward reality thanks to new technologies such as gene therapy. Believe that every life that does not give up deserves to be protected with all our efforts. The team of vascular surgeons will take care of your health and accompany your hope.

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